I sat next to my very first technical mentor for a few years, and he had no compunction about holding up a finger and saying "hang on" curtly when I'd start to ask something. If you all agree that it isn't rude in this context, I think that reaction can help. I do it myself occasionally and usually can keep about 80-90% of my flow.

Try doing that to your wife on work-from-home days at your own peril.