My wife and I live, work and travel from a 25' Airstream and can definitely relate to a lot of the point the post has made as well as the "decision fatigue" mentioned in other comments. It is tough to keep focus for 8 hours when your scenery is changing from week to week and there are so many new awesome places to explore. That said.. We are currently loving it with no plans to stop or slow today. Todays adventure is mountain biking in Bend Oregon.
Decision fatigue comes in with route planning, trying to figure out if that cool forest road everyone talks about will have cell service, where to fill up with water, where to dump the tanks... all of which are near constant. We could slow it down a bit and stay in an RV park a month or so, but we enjoy moving and don't enjoy the atmosphere of most private RV parks.