I was about to ask the same - the idea of node-webkit is awesome. It would also be nice weekend project to create a website where the user just uploads a zip file with HTML/CSS/JS and download three executables for Linux, OSX and Windows afterwards.

I don't think that gives you native OpenGL and other goodies described....or does it?

node-webkit is great, just wish there were great UI library (FOSS & MIT licensed) that looks exactly like a windows/mac/linux desktop application.