You can type on a straight keyboard with your wrists turned in like with an ergonomic keyboard.
A good way to describe it is that the home keys are not asdf jkl; but rather more like qwdc mkp[ . I don't have any real fixed home position though, my wrists always "float" over the keyboard. Particularly the right wrist spends more time near the brackets and slashes for programming.
I code, game on a standard keyboard, no issues - don't get me wrong, I've had RSI before, but it was down to technique, posture.