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"Much of the excitement we get out of our work is that we don't really know what we are doing." -- E. Dijkstra

Indeed, as a scientist and entrepreneur, I have realized that it is deadly to be paralyzed by not knowing what to do.

So Bre Pettis's advice stands.

I think the way it's presented (the use of "pretending" in particular) is poor, but I think the idea behind it is good. Not knowing what you're doing shouldn't stop you from doing it, it simply means you have things to learn before you're done. If you're willing to accept that and seek knowledge and help where appropriate (and don't deceive others about it, as pretending tends to imply), behaving as if you know what you're doing is a good means of personal growth and getting fresh ideas into a project you're joining.

there should be an emphasis on the "almost".