A buddy of mind wrote HandPlot for AutoCAD (way back in the day). It'd jitter the HPGL/2 output to mimic a drafter's pen drawn technique. The visual "draft" effect encouraged dialog, whereas the precision of normal plots shutdown discussion. (Looks like it's now a built in feature called Visual Styles, hmmm).
I've always wanted to do the same for hand lettering. Any one who's done drafting on the boards knows what I'm talking about. People used to take great pride in their unique lettering. Somehow parlaying that into one's design/contract drawings would be awesome.
I looked at PostScript and TrueType, but couldn't figure out how to randomize the letter forms. I never looked at OpenType.