You made my point regarding small scale simulation, but completely missed the rest.
> So they wire it like the brain is wired.
As if anyone knew how to do that. Even assuming that you can do both accurate micro-tractography and extract cell-by cell epigenetic information out of a single column, you'd still be missing other cricial information like individual synaptic strength.
I'm not talking about cortico-thalamic connections (required to model epilepsy) inter-columnar connections, and whatever regulation happens in the white matter.
Relying on the probability distribution of connections as a crude approximation is useful, but far from the real deal.