Well, it would appear to me this is one of the few posts on OpenResty. I recently discovered it myself as one of the faster options on the the TechEmpower Benchmarks. I know that this will lead to a benchmark flamewar, but that is where I first heard of it and started researching it.
http://www.techempower.com/benchmarks/#section=data-r6&hw=i7...
However, you might also notice that this project uses Lua (specifically LuaJIT) to run embedded in the server. I would think this avoids the problems partially. There is even a new MVC project budding out of this for Lua/Moonscript called Lapis, if that really assuages your concerns. Seems pretty micro, so I am not sure it is meant to really handle your security concerns. It was used on a demo site for a web game shop site that made it here a few months ago. Check it out; it is pretty cool.
https://github.com/leafo/lapis
As pointed out before, few frameworks I have researched care about security. Ironically, I think web2py is the only I remember having dedicated page space on doing OWASP evaluation against their code base from a long time back: http://www.web2py.com/book/default/chapter/01#Security). Others rarely mention it, and are total crap security wise. As others pointed out, frameworks are little guarantee against security unless, like the language and dev experience itself, prepare to know what the hell you are doing.
Final point, a much cooler complement might be the "Web Application Firewall" projects built into the web server itself to block typical injection attacks. NAXSI, specifically for Nginx, is a cool project and I will look into soon. Maybe this will interest you to.
https://code.google.com/p/naxsi/