It works much better over high-latency links (mobile). It is not bothered by saturated links, tolerates IP changes and losing the underlying connection like when you suspend your laptop and take it elsewhere.
I now have mosh connect to several servers in tabs when I run gnome-terminal the first time, and only disconnect on reboot. I also run a mosh-capable Irssi Connectbot fork on the phone[2].
It's a massive improvement, fixing many of the little annoyances of ssh.