One of the reasons we relaxed the strict methods that were adopted in the '70s was that we realized genetic material moved around all the time, Nature, in moens's delightful formulation, is a script-kiddie to end all script-kiddies.
No, I believe that we do not understand how far nature has taken us. We assume that genetic material moving around is accidental. I assume that most of the movement is intentional within the evolved system. I assume that we should not move it around without first at least considering that nature could be more advanced that we think it is. We should quarantine our changes.
Please explain how "intent" and "evolved system" have anything to do with one another. There is no "intent" in an evolved system.