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Oh, damn that's a mess. What OS is that?

Chrome 28 on Mountain Lion http://uk.omg.li/QP02

That's very strange, I'm running the same setup as well. Have you installed any system tweaks that change the way fonts are rendered?

Yes, but a font-weight of 100 is never a good or useful thing, it's terribly unreadable

Probably Windows. Chrome uses GDI on Windows instead of DirectWrite for some unfathomable reason: https://code.google.com/p/chromium/issues/detail?id=25541

Nope, it's Chrome 28 on Mountain Lion http://uk.omg.li/QP02