The only time you really want the active stuff is when you're traveling and there exists a lot of low-frequency noise, such as on a train or airplane. Looking around on Hydrogenaudio confirms that the QC are okay if that's all you need, and also that alternatives exist, such as IEMs, which might have a wider range of use as they simply have very heavy passive isolation.
The e5c's main problem is they are SO sensitive they are completely unforgiving about the amplifier used - almost anything with a gain block after a volume control is going to have too high an intrinsic noise floor for them to not show it up.
Here's what the wirecutter says about it: http://thewirecutter.com/reviews/best-noise-canceling-headph...
At home I also have the Sennheiser HD 600. I usually use the Bose -- the noise cancelling is nice even if you're not in a plane.
I'd be upset if my home environment were loud enough to warrant noise canceling, though.
In terms of pure isolation, Etymotic makes some of the best out there (>30dB isolation), and I think they sound absolutely brilliant.