Sort of... the faster you go, the more energy you need to accelerate even faster. The Orion design, IIRC, basically involves sitting on a big iron plate and tossing nuclear bombs under it. Each bomb can only impart a certain amount of energy and at some point you're not going to accelerate any faster unless you shed some mass.

You will shed some mass in the form of the bombs you're blowing up, and whatever you break off the bottom of the plate you're blowing them up against, and I think the design requires a front shield too which will also deteriorate over time and shed mass, but those all probably balance out around the 0.1c velocity.