Other carnivorous animals are rarely aware of the fact that they are using other sentient beings for food (although sometimes they do demonstrate an awareness of this), but we can't help but be aware of it. We justify it with a values system which says that it is morally permissible to eat creatures that aren't as smart or are otherwise just different from us. But that's a tenuous sort of morality, and I honestly think that it gnaws at us more than we usually admit.
Think about how aliens are typically portrayed in science fiction films. They've crossed unimaginable light-years to come to earth, and are immensely smarter than us. But nine times out of ten, once they get here, they've got nothing better to do than kill and more often than not eat us. Same goes for superior machine consciousness: in our mythologies, it almost always wants to kill and/or consume us. Why?
I think it's a reflection of our own insecurities: if there's any species out there that's truly smarter than us, we'd better hope that it doesn't share our value system -- because if it does, then it will see us as entirely legitimate to farm and eat.
So I choose to do unto other species as I'd like other species to do unto me. But of course that's just my personal choice.