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It will be interesting to see what the effect of both Gate's and Buffet's donations will be. It certainly is a good that a large chuck of capital and energy is going toward improving society, but putting that much capital to work may also cause significant inflation and negate some of the benefit.

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Inflation isn't the problem - GDP is $15T or some such, and they're investing this over time - so $150T is what they're comparing. Perhaps in niche markets they could do so.

The main problems of that much money is that you get into investment mode which is more conservative, top-heavy, etc. This means it's slower, less likely to find the best innovations, and lower social-ROI.

However, some problems require such capital - like what Elon Musk is working on at SpaceX, but again that's focused capital.

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