Exactly reproducing novel findings usually requires a significant investment into the underlying procedures, which most places will not undertake. Reproduction instead usually occurs as part of an extension of the initial findings. The complexity of biology means that the first findings are frequently not reproduced exactly the same way as the original, but this does not detract from the "direction" of the initial findings.
For example, the first finding might be that protein A promotes tumor growth by modifying protein B. An extension of these findings might be Protein A sometimes modifies protein B, and when it does tumor growth is stimulated, but it mostly does not modify protein B, it instead modifies protein C, which suppresses tumor growth. In this case, were the first results replicated? Yes, and no.
This is how most biomedical research proceeds...