The Bloomberg Terminal is a great example. There is nothing intuitive about is at all and using the mouse with it is quite painful. (Here's what a news screen in the terminal looks like http://www.businessinsider.com/type-this-command-into-your-b...)

However, every new feature we had to release needed to have every action accessible using the keyboard. There were best practices for using certain keys with certain actions (so that they were consistent across the features) and this was one of the most important things of an UI review.

I ended up using the keyboard always whenever interacting with the terminal. The Chief UI guy at Bloomberg was ex-Wall Street and told us that when he started working on his first job on Wall Street, someone came up to his PC and disconnected his mouse so that he would learn how to use the Terminal properly and efficiently.