If it's a matter of adding a couple slashes to 7's/Z's or to 0's, that should be reasonably straight-forward to do. In Glyphs, it would be a matter of adding a new shape for the slash wherever you want it. Then File -> Export and you're on your way.
(And obviously you might run into license violations if you're changing fonts you're not allowed to. This post isn't meant to address the legal side of it, just a guy at his desk fixing fonts for his own use.)
(Edit: typo.)
Confusing capital 'Z' with numeral '2' is possible for me; luckily, capital 'Z' is really uncommon in what I create. If I feel it might be a problem, I'm likely to increase the curviness of the top of my numeral '2'.
Anyway, this is all handwriting. Typefaces, which aren't scrawled in haste, have a lot of other tricks they can use to distinguish glyphs.