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Presumably this is a problem that's been long-solved in scale up manufacture, and something you should just be concerned with on the small scale.

Generally though - yes - anything water-soluble is pretty easy to get very controlled concentrations of, since you can dilute until your in the operating range of your weighing machine.

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I'm not much of a biologist and I may just be spouting what I've heard in the past, but I think all the water soluble vitamins and such are totally safe and impossible to OD on, it is the fat-soluble ones where there's the potential to OD.

EDIT: Mostly correct! Fat-soluble vitamins build up in the fatty tissues and are much slower to release and are almost always responsible for Vitamin Poisoning, water-soluble vitamins are easily excreted in the obvious way.

There are exceptions though, you can overdose on some of the B vitamins which are water-soluble, I didn't follow up to find out why that is.

http://en.wikipedia.org/wiki/Vitamin_poisoning

Nothing stops you from using a lipophile solvent rather than a hydrophile in preparing these dilutions.

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