I didn't mention C :)
I wouldn't drop down to C ever at application level. There is virtually no need to do this these days without introducing more risks from a security and memory perspective and the inevitable situation of "integration hell". I'd rather throw it in a JVM than drop to C. Then again if I started with a JVM I wouldn't have the problem to start with as it solves both ends of the problem. The CLR is equally applicable here. Go hits the mark too.
From my experience here dealing with a massive 100kloc python project. Python maintenance:
a) Horrible to refactor. I mean really horrible. You don't get everything right the first time and when it comes to fixing that it's hell.
b) no type safety or contracts which is hell when working with other developers.
c) indentation issues which are totally horrible at merge time as it introduces a shit ton more work to do.
Reliability:
a) Some algorithms don't scale the same way as they do in other languages due to the points the article raises. It gets to the point that for something in Java is O(N), it can approach O(N^2) due to all the dict fudging and copying which is not good.
b) It's slow anyway - I mean really slow. If something feels slow, it is slow. PyPy may fix this but (c) below causes an issue as well.
c) Optimisations aren't consistent across python versions (consider how crappy IO was in the first py3k drop).
I wouldn't use Python for a new project now. The only utility I see is quick disposable bits of glue.