Founder Andrew Welch is an RIT grad: http://en.wikipedia.org/wiki/Ambrosia_Software
I purchased Uplink before I knew it was produced by a local, and joined the fraternity before I knew that one of the brothers had been involved to produce a game I liked. I am sorry to hear that they are closing up shop!
* that<- if (I do not have inside information)
Sometimes I wonder what the software job market is like in Rochester these days.
I know that Rochester used to be a boom town (Kodak, Xerox, Bausch and Lomb, probably others) and a place of cultural and moral significance (Frederick Douglas, Susan B. Anthony). It's a nice place, and I spent 4 years there. But it's definitely a place in decline. The same way that Detroit was a boom town and now is not. If I made a similar sideshow saying "You're welcome. -Detroit", would that prove anything?
(It's also ironic that this slideshow assigns Rochester the credit for the Xerox Palo Alto Research Center. Was it not corporate HQ in Rochester who made the bad decisions not to do more to productize those gains?)