Personally I'm not a fan of antidepressants. For me, Prozac had the side effect of extra-sensory perception: I couldn't do anything without having immediate karmic effects on people I knew who lived hundreds of miles away. I'd be sitting in bed talking to my wife about (essentially unpredictable) events that would happen to take place the next day. People think they might want those kind of powers, but you can count me out. I lasted about a week, but it took most of a month for the metabolites to wash out of my system.

One tablet of lexapro causes my interest in sex to disappear entirely for a week. Personally I think this simplifies my life, but three days of sleeplessness is quite a price to pay.

A friend of mine started taking Effexor, but then we found accounts of how it's impossible to stop taking Effexor: blood-curdling stories about pharmacists who'd dissassemble the pills and reassemble them to titrate the dose down, and who'd still be unable to get the dose to zero. He stopped in three days, before the damage was done.

Anyhow, all of those drugs affect serotonin metabolism, as do the 5-HT2A agonists that some people call psychedelics or entheogens. Alexander Shulgin did a 30-year research program on psychedelic phenethylamines (drugs structurally related to dextroamphetamine, mescaline and ecstacy) and found that certain drugs in that family have a synergism with alcohol much like what the author of that article describes.