I discovered line_profiler last week when I was trying to learn how to profile in Python. You show it your code, and it shows you what's slow - this is exactly what a profiler should be.
I really want to start a campaign to get something similar built for JavaScript. JavaScript has the most diverse user base (from people who barely know how to use their computers all the way up to Googlers), yet our profiling tools can be intimidating/hard-to-decipher even for people who are quite comfortable with the rest of the language.
My mental model for my code is my code. Showing me a data-grid with a tree of function calls (many of which may be in external libraries I don't control) isn't nearly as helpful as showing me, line-by-line, how fast my code runs. (This is especially true since not every line that takes time to run makes a function call.)