The two things I dislike about Firefox. The development tools are funky. I am sure many people like them but when you are used to firebug / webkit tools the default Firefox tools are a bit of a shock.
The second issue is the lack of tab sand-boxing. A fairly large part of my job is testing for edge cases in our products. Our products are JavaScript heavy. I often find issues which crash the browser... well.. they crash Firefox. In Chrome the tab shows an error in the console and I have the option to close the tab. In Firefox I never get an error in the console. The whole browser freezes and stops responding.
It would be fantastic if Firefox sandboxed tabs to stop the entire browser crashing.