That would be an incredibly bad idea. The implementation of SBCL (and CMUCL, upon which SBCL is based) is second to none--it has an optimizing compiler (available at runtime) with code-generation backends for architectures from x86 to MIPS; fantastic support for type inference, inline expansion, modular arithmetic, unreachable code deletion, constant folding, control optimization, generational garbage collection (doesn't python still use reference counts?)... amongst a bunch of other stuff.
http://shootout.alioth.debian.org/gp4/benchmark.php?test=all...
Benchmarks are of course arbitrary, but no matter what way you dice things, SBCL is vastly superior to Python's crappy VM. In the case of the link above, over 10 times faster.