I think it's great. There are many fonts and colors and variation, but the design still has clear sections (short product descriptions, detailed about company blurb, client videos, buzz etc.), and more important, there are points in the design that grab your attention and suck you in; these are the big icons at the top with large speech bubbles and the "A Better Way To Work" heading. This means as you glance over the page your eyes will find a place to land, and I think the copy itself is very well done -- short and to the point -- which means I'm likely to actually read it.

One thing that always bothered me is the navigation 37signals tend to use. It's stuck at the very top of the page and is set in a very small font size. Current locations are also not highlighted on some pages. Perhaps they don't rely on it at all and instead focus on getting people to click on calls to action inside the content.