I blocked third party cookies in Chrome for awhile and finally gave up. It broke a surprising number of things, particularly Disqus embeds. Also the Instapaper bookmarklet although I admit that's a nerdy special case. Hopefully Firefox will have a way to let the user enable the few places where third party cookies are desired. That's a hard user interaction to get right.
(Disqus apparently now works without third party cookies: http://help.disqus.com/customer/portal/articles/466235-enabl...)