I can't speak for everyone, but I am of the opinion that glucose synthesized in a lab requires no special evolution on the part of humans to process.
Glucose is a catch-all term referring to both chains and cycle structures based on a certain "base" of atoms, and that base is chiral -- it is different from its mirror image. Glucose thus refers to both L-glucose and dextrose. You can process both in some ways -- they both taste sweet to you. But you can't metabolize L-glucose, because the first step uses a similarly chiral enzyme called hexokinase, which only fits properly with dextrose.
Most lab synthesis of glucose (which is to say, pretty much all lab synthesis which is not bio-synthesis) is symmetric under mirror reversal and thus produces 50% dextrose, 50% L-glucose. So about half of the glucose synthesized in a lab requires special evolution on the part of humans to process.
Avoiding taking prescription drugs unless you really have to (ie are going to die), as I do, is not a bad way to live. Just because natural things will kill you, does not mean we should not avoid man made things. So I do not take pills for headaches, for sleeping, etc...
You thinking is because you can die by a bear, you should not look before crossing the road.
Nope. Simplistic, backwards thinking.
There's nothing dangerous about taking a valium to help you sleep once in a while, unless you have a specific allergy. And that is what you would be instructed to do if you were suffering from insomnia or panic attacks.
They are controlled because they are dangerous in large amounts and addictive if used frequently.
Some antibiotics are controlled because people see them as a magic cure-all and would take them for everything, which would even more rapidly lead to resistant strains of bacteria and make the antibiotics useless.
So sure, some drugs are dangerous when used as instructed, but many are only dangerous when abused, and some have wider implications for society.
But consider the flip side; just because some man made things can kill you, does not mean we should avoid man made things.
You thinking is because you can die by a bear, you should not look before crossing the road.
You are really reaching.
Being in pain when there is a simple, cheap, safe, effective medication is a bad way to live.
This works for non extreme pain, of course.
All of these things help keep pain going on longer.
For long term pain with no worrying cause you should carefully take pain killers and keep moving. Things like lower back pain (which can have serious causes, so get it checked) get much worse if you stop exercising, but get better if you get appropriate exercise.