At some point it needs to come down though, one way or another. Not many are going to invest in a company which is guaranteed to have a P/E of > 200 indefinitely. This would mean a very low return on investment.
Now their investors may care, and there may be board fights and so on, but if Bezos can control that then he has some leeway to build the company he wants. It's pretty impressive, really.
And it's very intriguing what's going on in Cambridge (MA). A lot of hiring and work and what-not yet nobody seems to know what they are doing.
That said, there are exceptions to every rule. I'm not aware of any other companies that currently exhibit such a high P/E.
But in a long perspective, there needs to be a small ratio between what you paid for the stock and what the company earns if it is going to be a good investment. FYI I am heavily invested in Tesla Motors, which currently has an undefined/negative P/E ratio.