The depression that we can't get out of alone -- when we lose all hope for everyone -- that's the hardest to fight. Losing your will to live can quickly lead to suicide. And it's hard to tell from someone else's perspective that you're suicidal because you've pushed everyone away.
I think the only cure to the second form of depression is to practice a healthy state of mind everyday. Enjoy life and friends that are close to someone. Always share your problems with a close person (someone you truly trust). You must have the will to live. Giving up isn't the answer to all your problems because someone else will have to inherit your problems. Which isn't fair for that someone!