I tracked my learning performance over two years under a range of conditions, including trying a treadmill desk. I found at 1.2mph my error rate (compared to sitting) was 50% less, and I could comfortably study for 2x as long. The trick is to keep the speed quite low, and have your PC at a comfortable position. I now do all my work this way, with an adjustable desk, which I put in sitting position only an hour a day.
More details on my experiment are in this talk I gave last year: http://quantifiedself.com/2012/05/jeremy-howard-on-language-...