I'd imagine the http://en.wikipedia.org/wiki/No-cloning_theorem has something to say about a brain upload. Maybe an approximate copy is good enough?
Greg Egan is one of my favourite modern sci-fi writers. He explores interesting and hard ideas about what it means to be human by placing humanity in thought provoking situations.
In 'The Jewel' we have developed an implant that learns how to 'be' the host. At some point your brain is removed and the jewel takes over your functioning. The thing is, what happens when something goes wrong... boom boom booooom!!?!?!
But really, read him if you are into sci-fi.
[0] http://en.wikipedia.org/wiki/Greg_Egan
[1] http://en.wikipedia.org/wiki/Axiomatic_(story_collection)