Maybe. Much as I'd like to believe it, there are some things that can't be bootstrapped. Actually there are many things. We just don't do them because the VC's aren't funding them either. Perhaps they'll go back to it.
OTOH, VC access is one big reason innovation gets centralized to places like Silicon Valley. Reduce that friction and it can spread out more. Still doesn't fix the issue of networking for talent which is another network effect that clumps innovation.
I did my first startup in Houston, Texas. It was great. Extremely cheap. Built a product and got to profitability on about $600K of capital. Moved the company to Silicon Valley before ultimately selling it to Borland (it became Quattro Pro).
Houston worked for development because I could get talent out of Rice University and Univ. of Houston. Infrastructure was cheap because they were having a real estate crunch at the time. You could get free rent for 2 years in exchange for signing a 5 year lease.
What was hard was the marketing and networking. After riding planes to go to the East and West Coasts to get the product reviewed, I decided we had to move the company.
In the Internet age, that may be a lot less true. No particular advantage to doing my current bootstrap (CNCCookbook) in Silicon Valley other than that's where I live. Houston would be a lot cheaper.