* What will be the geographic center of innovation?
* What industry will the innovation be in?
These are orthogonal. I can't answer either of these. I honestly have no clue. I'll make one solid prediction, though:
I don't know what the Big Thing of 2030 will be, but it will involve computation. It'll be far outside of traditional IT (the use of computers to implement 20th-century business ideas) and social media (same, but for 21st-century cultural experiments) but whatever is Big during 2030 will require a lot of skill when it comes to computation.
Of course, I have no idea whether this will happen in Northern California or some other corner of the world.
What I think is clear is that VC-istan innovation is over. The problem is that the VCs talk to each other and collectively decide who's hot and who's not. So, instead of getting true risk-taking, you have selection by committee in the funding process. That is starting to fail.