Using AI for the ComfyUI API or workflows worked pretty well for me even early this year.
However, today I don't see a reason to use ComfyUI at all.
For Qwen Image 2.1, I had Opus 5.5 create a backend outside of ComfyUI and it was able to make generation take 20% less time with some optimizations.
The optimizations it implemented were caching the text computation in Qwen Image 2.1 rather than including it in every step, fusing projections into a larger matrix multiplication, and decoding the VAE in horizontal bands or something like that.
If there was anything interesting in ComfyUI nodes, I imagine I could just have the AI adopt the relevant code instead of dealing with ComfyUI or custom nodes.