For one thing space based observation is very good and has a much faster turn around now days.
Back then photography was film based, satellites would fly take pictures and release the film in a pod to reenter and be recovered mid flight[1].
And on the other hand altitude and speed does not buy as much survivability as it did back then.
Fighters flew at a maximum of 1.5 mach and missiles at 2-2.5 mach.
S-400s for example can launch interceptor variants that can intercept targets at almost a hundred thousand feet moving at 14 mach. I know that is for ballistic targets, but I doubt an aircraft flying at a similar altitude even at hypersonic speeds would have much luck.