I can recommend turning off biters, or at least biter expansion. That way you can at least focus on building your factory, without getting distracted by attacks.
Using a main bus where your factory is built in comb like rows on one side (so you can make the bus wider on the other side) is simple and will work pretty well for the starter base (i.e until you fire your first rocket and "win" the game).
I often split my starter factory in 4 quadrants with sufficient space for belts between them:
1. Smelters
2. Main bus based factory
3. Oil processing
4. Personal fabrication and mall (especially once logistic bots become available)