Sort of interesting how Python has got rid of the GIL. Serialization of data securities is still something relevant though and I’m not sure if you should use pickle still?
That was my first web kind of framework. The naivette of Zope still amuses me endlessly to this very day.
It tried to be cool, made ALL the wrong choices, and died silently with people just moving on.
I will never recover from debugging ZODB backed by Oracle. Well, somewhat backed.
Who, like, who thought it was cool to have a pickle-based, mostly in-memory, single process, aaalmost transactional database?!
I was more traumatized by the Java-based product from Open Market (acquired from Future Tense back in the day), and all the horribleness that that entailed. Starting from XML as a template language, then seemed to get only worse. Nothing like having multiple content areas all rendered as 500 Server Error pages within one page, when it all goes sideways.
If you need something safe then you really need to identify your requirements and your threat model first anyway; I wouldn't blindly reach for a one-size-fits-all solution in any programming language.
(Although I would do a quick check to see JSON or TOML is sufficient and practical.)