Wife and I used to be avid drinkers but with the expansion of legal cannabis, it's just not as good of an option. I'll still make myself a negroni or an old fashioned on occasion, just because they're delicious, but I haven't drank-to-get-drunk in YEARS. If I'm actually trying to unwind (and who isn't given the sheer STATE of our world!) I'm spoiled for choices of substances that both don't interact with my depression nearly as badly as alcohol and, as a bonus, don't make me gain weight like an inflation fetish character.
The alcohol industry won spectacularly for decades a game of public policy and image where alcohol, a substance connected to industrial quantities of human death and suffering, was somehow the "accepted and normal" way to get fucked up when you wanted to be, even though again, numerous alternatives existed that were better for you. They're going to go through a similar process to tobacco I think, which is to say: it'll still be around, but it will shrink to an industry sized appropriately for the actual demand of it's product.