Also, there are high grade derived products that do exactly what's on the label.
For an example of reasonable use: if you want to lower anxiety a bit, which is a primary driver of alcohol use, you can now reliably get a high CBT strain, or CBT gummies, or CBT vapes, and they are generally less dangerous and less addictive than other chemical solutions.
This would also hold for decriminalising party drugs. Most of the fentanyl deaths for instance are in people that didn't even know they're having fentanyl.
You can make an argument in the other for alcohol. Yeast can only ferment up to a certain alcohol concentration and then they die. But that doesn’t tell us much about the potency of consumer alcohol products because we have a variety of manufacturing processes for controlling alcohol concentration. These it’s less common, outside of home production, to just accept whatever unpredictable thing the yeast are doing and call it good.