When it comes to math, that's what people are familiar with so that is a factor. But function application is prefix as well for the majority of mainstream languages.

There's nothing "natural" about reading. We've not evolved as a species to have natural reading abilities. Of just about anything - be that cuneiform, hieroglyphs, katakana, math formulas or Sanskrit. Every person has to be taught how to read. A Mandarin-speaking person may argue that their writing system is "more natural" simply because it's one of the oldest and most widely used in history. Would you buy that argument?