A while back they renamed some gene names so they wouldn't trigger Excel's autocorrect: https://www.theverge.com/2020/8/6/21355674/human-genes-renam...
People also used it to collect COVID data during the pandemic, and a lot of data was lost because someone accidentally opened it in an older version of Excel.
It's one of my pet peeves. Excel should not ever be used to maintain data. It's a fancy calculator.