For us, it is a matter of not being able to build and maintain meatspace social connections - reasons vary, including severe social anxiety, poor socialization (in part due to issues with physical development), and physical isolation; if there is a common thread, it is a history of a dysfunctional family life that disrupted development.
It's very frustrating when women center themselves in these kinds of conversations, and use that spotlight to assume and project the worst. There is a consistent unwillingness to even try to understand the perspective of socially-disadvantaged men, or to engage genuinely with the notion that their needs are unique, and uniquely unmet, when compared to that of women and better-adjusted men.
It makes it difficult to get genuine grievances taken seriously; people are always looking for ways to wash their hands of persistent and onerous social issues, and being told, by someone perceived as socially-successful and authoritative, that they can is all the reason they need.