Is nicotine a problem, though? I'm not a cigarette or vaping guy. I do like a nicotine pouch, and I love an evening pipe. My understanding is that nicotine is not much of a problem, but the smoke / vape contaminants are where the real hazard lies.
That is what is left if you ignore the big one, which is its addictiveness. By itself that is probably not directly harmful, but the ways of consuming nicotine mostly are. Nicotine pouches carry some health risks, but are obviously not nearly as bad as snus and other crap like that containing tobacco.
As for the nicotine: yes, it's not great for your cardiovascular system. One Juul pod per day probably twice as bad as drinking three Starbucks grande drip coffees. However, the harm reduction of vaping is profound. Smoked tobacco is just devastatingly worse: smoke has carbon monoxide, formaldehyde, acrolein, and these are on top of the radioactive polonium and lead isotopes.
It's crazy seeing a lot of fearmongering (not saying that's what you're doing, but it is certainly a prevailing narrative) about vaping when, per the data, it's the strongest smoking cessation tool available outside prescription drugs and a massive harm reduction even if it's just a permanent substitute.