things like color rendering, sharpness, screen door/morie, motion blur, and yup even good ole depth queues in the lens system all show up as artifacts.
case in point, outside of a few specific niche cases like the mandalorian, that virtual production video wall thing is not actually being used all that much because of the amount of post shoot cleanup required to fix all those issues, it wasnt actually that much cheaper and its not really better either. especially when you factor in how hard it is to shoot that way.