Ah this is interesting. Essentially the idea is that the compute can try and move into positions that it can evaluate but humans might have trouble evaluating because of the board state's complexity?
When playing white in handicap games, you want to make your opponent uncomfortable.
Play moves where the simple/safe/obvious move is just a little bit bad. Force them to choose between complex fights or a slow death of 100 slightly suboptimal moves.
It feels really wrong to defend like 10 times in a row, so if you make them do that they'll lash out at the wrong time and you can take advantage.
You also want to look for moves where...even if their best response means it's even or a little bit worse for you, there's ~reasonable responses where you win out or it goes complex.
A lot of the time it's not even crazy complex fights, it's more just situations where the judgement of what is more points is difficult.
(Note: most of this stops applying as strongly if it's a teaching game, which most handicap games are, there you have other considerations besides winning)