If you submit 16 contiguous read requests the system will just merge them into one large read request.

Modern SSDs tolerate moderate queue depths very well, but piling on the I/O queue also incurs tail latency jitter unless you're able to ensure the queue depth stays in the moderate range and never goes higher. All else being equal, fewer larger requests is better for I/O latency (though read amplification for the sake of reading more data obviously doesn't help anyone). Though in this scenario, we're mostly comparing the syscall overhead of a single preadv against io_uring bookkeeping for multiple preads, regardless of how you submit the reads they end up being the same operation.