Judging from the kind of content creators nebula hosts I'd imagine they do in fact have the kind of nerdy audience that notices miniature font differences.
As a visual designer, sure, it is you job. As a computer user whose ultimate goal of using a computer is something else... I am kind of an old fart, but I often find that the best content is often found in conjunction with "font-family: sans-serif".
Day to day, I use open source fonts that Butterick recommends. But once in a while, I like using just nice stuff. It's like a nice fountain pen for others.
but again, I am an old fart who is sad gopher lost.