The human genome is 800MB, (and 500MB with compression according to GPT) so that part is easy.
I think the problem is that the conversation drifted from "all useful human knowledge" to "enough knowledge to do my job".
Both a human and a current large model will bring up unprompted some tax regulation that applies in your district that could matter to your task. A small model won't know the tax code of every city in the world, as it's probably impossible to fit, and it's the kind of thing that unless you already know about, it's very hard to search for, let alone come up with unless specifically prompted about something tax related.
Unless we start having different small models trained for a certain profession for a certain city, I think we'll need those trillion parameters.