Yes, you can run Podman with different OCI runtimes, in the same way as you can run Docker with different OCI runtimes, and some of these OCI runtimes are microVM-based.

This is not what the person I was responding to is doing, though.

As for differences between the krun OCI runtime and Docker Sandbox (which also uses libkrun), let's please continue the discussion here: https://news.ycombinator.com/item?id=49240662 .